Caffeine-induced currents in the frog sympathetic neurons
نویسندگان
چکیده
منابع مشابه
Dihydropyridine actions on calcium currents of frog sympathetic neurons.
Dihydropyridines (DHPs) generally have little effect on whole-cell calcium currents of neurons, even at concentrations far higher than those effective on muscle. Either neuronal calcium currents are much less sensitive to DHPs, or only a small proportion of the current is DHP-sensitive. We find that DHP agonists and antagonists act at low concentration on calcium currents in frog sympathetic ne...
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Neurons from bullfrog sympathetic ganglia were voltage-clamped using a single microelectrode in Ringer solution with tetrodotoxin. The M-current (Adams et al. 1982 a) was markedly reduced during the rhythmic outward potassium current induced by caffeine (1-5 mM). This indicates that an elevation of the intracellular concentration of calcium ions by caffeine not only activates the calcium-activa...
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Frog sympathetic ganglion neurons exhibit a novel Ca2+ uptake mechanism, release-activated calcium transport or RACT, which is manifest in both cytosolic and store [Ca2+] signals as greatly accelerated Ca2+ uptake after Ca2+ release from internal stores. RACT is activated by Ca2+ release but not by Ca2+ entry and serves to selectively refill Ca2+ stores after release. RACT lowers cytosolic [Ca2...
متن کاملCalcium currents in bullfrog sympathetic neurons. II. Inactivation
Calcium currents in bullfrog sympathetic neurons inactivate slowly and partially during depolarizations lasting 0.5-1 s. There is also a slower (minutes) inactivation process with a broad voltage dependence. An irreversible loss of current (rundown) is prominent with low concentrations of intracellular Ca2+ buffers, with either Ca2+ or Ba2+ as the charge carrier. The extent and rate of the more...
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The effect of recombinant human tumor necrosis factor-alpha (rhTNF) on calcium currents of cultured neurons from neonatal rat superior cervical ganglia (SCG) was studied using whole-cell patch-clamp technique. We found that rhTNF-treated SCG neurons exhibited increased calcium current density without significant alteration in the steady-state parameters of activation and availability. The fract...
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ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1988
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)57168-2